Research projects

Major current and recent projects, with our partner institutions and funders.

Current projects (8)

A Wuqu’ Kawoq health worker provides health education in a patient’s home.

Implementation of a National Model for Diabetes and Hypertension Treatment in Guatemala

2024–present

This project is working in collaboration with the Ministry of Health and INCAP to scale up diabetes and hypertension treatment in public health facilities around the country.

Partners
INCAP
Funding
World Diabetes Foundation; NIH/NHLBI (K23HL161271, R01HL178752)
A health worker uses a smartphone application during a home visit.

Artificial Intelligence and Quality Improvement to Reduce Neonatal Mortality

2024–present

This project builds on Wuqu' Kawoq's long standing Mobile Health Program, but now focusing on specific quality improvement initiatives, including enhanced real-time smartphone decision support, to detect neonatal complications and prevent neonatal deaths.

Partners
Emory University
Funding
Google Nonprofit Foundation
A low-cost handheld Doppler ultrasound device used during a prenatal visit.

AI-Driven Low-cost Ultrasound for Automated Quantification of Hypertension, Preeclampsia, and Fetal Growth Restriction

2023-2027

In low-resource settings, high rates of perinatal mortality are due in part to challenges accessing affordable technologies to screen and monitor high-risk maternal-fetal conditions, such as fetal growth restriction (FGR) and preeclampsia. To address these issues, we are using artificial intelligence to develop techniques for predicting FGR and preeclampsia from low-cost hand-held maternal and fetal Doppler recordings.

Partners
Emory University
Funding
NIH/NICHD
Maize being handled and prepared in a rural Guatemalan household.

Aflatoxin Exposure, Growth Faltering, and the Gut Microbiome among Children in Rural Guatemala

2023-2027

We are studying the role of aflatoxin exposure on child growth, and whether the effect of aflatoxin is mediated by the gut microbiome and inflammation. We evaluate aflatoxin exposure and examine markers of inflammation, gut microbiome composition and function, and microbial nutrient extraction and aflatoxin microbial biotransformation.

Partners
ASU- Arizona State University
Funding
NIH/NIEHS
Agricultural workers in a Central American field.

Exploring Risk Factors and Predictors of Endemic CKDU in Agricultural Regions of Four Central America Countries

2022-2028

Chronic kidney disease of unknown origin (CKDu) has taken a terrible toll on young working families living in rural areas of Central America. This project identifies risk factors for CKDu and decline in kidney function in four Central American countries: Costa Rica, Panama, Nicaragua and Guatemala. The work is conducted through the SALTRA (Central American Program for Health, Work and Environment) network, connecting locally-based universities, NGOs, governmental organizations, public health authorities and local healthcare workers.

Partners
Programa Salud, Trabajo y Ambiente (SALTRA), Universidad Nacional de Costa Rica
Funding
NIH/NIEHS/NIDDK
Two health workers review an infant development app on a smartphone with a mother and grandmother beside a swaddled newborn.

Mobile Health Intervention to Promote Positive Infant Health Outcomes in Guatemala

2021-2026

The objectives of this project are to develop and determine the effectiveness of an mHealth smartphone technology which can be used to engage primary caregivers directly in the active monitoring of their infants’ development, and to provide tailored feedback and support for the provision of nurturing care and positive infant developmental outcomes.

Partners
CHLA-Children's Hospital Los Angeles
Funding
NIH / NICHD (PI Beth Smith, Children’s Hospital Los Angeles)
Trial
NCT05106894
The ELEGUA pilot survey team standing together in a pine forest clearing in Guatemala.

Longitudinal Study of Aging in Guatemala (ELEGUA): Pilot Survey

2025–present

Pilot study for the Longitudinal Study of Aging in Guatemala (ELEGUA), a planned nationally representative, population-based aging cohort modeled on the Health and Retirement Study and Harmonized Cognitive Assessment Protocol.

Partners
University of Michigan, INCAP, University of Pennsylvania, University of Southern California
Funding
NIH/NIA (R21AG090819); University of Michigan Center for Global Health Equity
The K'ASLEM study team outside, several members wearing traje típico.

Food Supplementation and Behavioral Counseling to Reduce the Double Burden of Malnutrition (K'ASLEM)

2024–present

Randomized trial testing whether food supplementation plus nutrition and lifestyle counseling for pregnant women can improve both maternal weight and infant growth in Maya communities in Guatemala, where child undernutrition and adult obesity commonly occur side by side.

Partners
INCAP, University of Michigan, Harvard Medical School
Funding
NIH/NICHD (R01HD114708)
Trial
NCT06750120

Completed projects (12)

Community members meeting outdoors in Guatemala.

Local Advocacy and the Power of Community for COVID Recovery

2023-2025

This interdisciplinary project drew together scholars of, and community organizations in, Canada, Brazil, and Guatemala. It explored the pandemic lived experiences of ‘small’ and ‘local’ health and service organizations and activists.

Partners
University of Manitoba
Funding
New Frontiers in Research Fund
Workers in an agricultural workplace in Central America.

Promoting Safe and Healthy Workplaces in Honduras, Guatemala, and El Salvador

2023-2025

The Promoting Safe and Healthy Workplaces in Honduras, Guatemala, and El Salvador (PREP for Change) project worked to improve occupational safety and health (OSH) conditions for workers in the sugar and garment (maquila) sectors. It focused on workplace illnesses and injuries, chronic kidney disease of non-traditional causes (CKDnt), and COVID-19.

Partners
La Isla Network
Funding
US DOL
A young community member in a mask and face shield holds a large cut-out syringe with the Spanish slogan “Vacúnate sin miedo” (Get vaccinated without fear).

Understanding Vaccine Acceptance and Messages among Indigenous Populations

2022-2025

The objective of this project is to understand social networks in indigenous communities as a way to address vaccine concerns and increase confidence in COVID-19 vaccines.

Partners
UCSF – University of California San Francisco, Stanford Center for Health Education | Digital Medic
Funding
Vaccine Confidence Fund
A mother holds her baby while older children play nearby during a child development visit.

A Hybrid Effectiveness/Implementation Trial of the International Guide for Monitoring Child Development

2021-2026

The aim of this study is to conduct a hybrid effectiveness/implementation assessment of the International Guide for Monitoring Child Development (GMCD) in two LMIC settings, India and Guatemala, within established rural CHW programs. The primary objectives are (a) to evaluate the real-world effectiveness of the GMCD; (b) to use an implementation science framework to understand barriers and facilitators to effective population coverage, provider implementation, and maintenance; (c) to conduct an economic evaluation of the GMCD.

Partners
Brigham and Women's Hospital
Funding
NIH / NICHD (PI Peter Rohloff, Brigham and Women´s Hospital, Inc.)
Trial
NCT04665297
Eggs used in the Saqmolo’ complementary feeding trial.

Effects of Complementary Feeding of Eggs on Infant Development and Growth in Guatemala

2020-2023

Investigating the impact of daily egg consumption during the period of complementary feeding, in addition to the standard nutritional care provided by Wuqu'Kawoq, compared to the local standard of nutritional care alone on childhood development.

Funding
American Academy of Nutrition and Dietetics
Trial
NCT04316221
A wearable movement sensor placed on an infant’s leg.

Wearable Sensors for Early Identification of Poor Neurodevelopment in Guatemala

2019-2022

Evaluating new technology to detect early developmental delay in infants at risk.

Partners
CHLA-Children's Hospital Los Angeles
Funding
NIH / NICHD (PI Beth Smith, Children’s Hospital Los Angeles)
A family tends a home garden in rural Guatemala.

Evaluating a Family-based Nutrition and Garden Intervention in Rural Guatemala

2019-2021

Investigating integration of home gardening into nutrition interventions to improve growth and diet quality for stunted children.

Funding
Academy of Nutrition and Dietetics.
Trial
NCT03689504
A Wuqu’ Kawoq staff member uses portion-size teaching aids during a home diabetes education session.

Scaling-up Self-management Interventions for Type 2 Diabetes

2018-2021

Using an implementation science framework to evaluate the impact of a home-based self management intervention for adults with type 2 diabetes in two health districts in central Guatemala.

Funding
World Diabetes Foundation
A field team member collects health measurements during a population survey.

Population-based Survey of Chronic Kidney Disease

2018-2021

Representative, population-based study surveying prevalence and risk factors for traditional and nontraditional chronic kidney disease in adults in rural Guatemala.

Funding
NIH / FIC
A care navigator accompanies a patient at a health facility.

Care Navigation to Improve Obstetrical Care

2017-2020

Using a quality improvement framework and care navigation to improve patient satisfaction and emergency obstetrical referral outcomes.

Funding
Grand Challenges Canada
A traditional Maya midwife uses a smartphone during a prenatal visit.

mHealth Technology to Support Obstetrical Care

2015-2019

Using smartphones and decision support mHealth applications to support identification and referral of high-risk pregnancies by lay midwives.

Funding
NIH / NICHD (PI Gari Clifford, Emory University)
Trial
NCT02348849
A home visit focused on infant feeding and child development in rural Guatemala.

Individualized Home-based Interventions to Improve Diet Quality and Developmental Outcomes in Stunted Children

2015-2017

Investigating optimal strategies for empowering caregivers and improving nurturing care for infants at risk.

Funding
Grand Challenges Canada
Trial
NCT02509936